Research progress on anti-inflammatory mechanism of natural sesquiterpenoids.
10.19540/j.cnki.cjcmm.20180726.013
- Author:
Li-Min GUO
1
;
Jie-Li LYU
1
;
Lai-Bin ZHANG
1
Author Information
1. School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, China.
- Publication Type:Journal Article
- Keywords:
anti-inflammatory;
mechanism;
research progress;
sesquiterpenoid
- MeSH:
Anti-Inflammatory Agents;
pharmacology;
Dinoprostone;
Humans;
Interleukins;
MAP Kinase Signaling System;
NF-kappa B;
Nitric Oxide;
STAT Transcription Factors;
Sesquiterpenes;
pharmacology;
Signal Transduction;
Tumor Necrosis Factor-alpha
- From:
China Journal of Chinese Materia Medica
2018;43(20):3989-3999
- CountryChina
- Language:Chinese
-
Abstract:
Sesquiterpenoid is a kind of compound widely distributed in nature, which has a wide range of biological activities, such as anti-inflammatory, anti-tumor and immunomodulatory activities. This paper would review the anti-inflammatory mechanism of sesquiterpenoid. The mechanism is mainly by inhibiting the activation of nuclear factor (NF-κB), mitogen-activated protein kinase (MAPKs) and signal transducers and activators of transcription (STAT) signaling pathways and down-regulating the inflammatory gene expression including tumor necrosis factor- (TNF-), prostaglandin E₂ (PGE₂), nitric oxide (NO), interleukin-1(IL-1), IL-6, IL-8 and other inflammatory factors. Thereby, the production and release of inflammatory cytokines are reduced to exert anti-inflammatory effect. This review is intended to provide reference for related research.
