Ferroptosis pathway and its intervention regulated by Chinese materia medica.
10.19540/j.cnki.cjcmm.20180517.001
- Author:
Wen-Hui XU
1
;
Cang-Hai LI
2
;
Ting-Liang JIANG
2
Author Information
1. Research Center of Artemisinin, China Academy of Chinese Medical Sciences, Beijing 100700, China.
2. Tang Center for Herbal Medicine Research, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
- Publication Type:Journal Article
- Keywords:
active ingredients;
ferroptosis;
ferroptosis inducers;
ferroptosis inhibitors;
traditional Chinese medicine
- MeSH:
Apoptosis;
China;
Drugs, Chinese Herbal;
pharmacology;
Humans;
Iron;
Materia Medica;
pharmacology
- From:
China Journal of Chinese Materia Medica
2018;43(20):4019-4026
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a new form of regulated cell death which is different from apoptosis, necrosis and autophagy, and results from iron-dependent lipidperoxide accumulation. Now, it is found that ferroptosis is involved in multiple physiological and pathological processes, such as cancer, arteriosclerosis, neurodegenerative diseases, diabetes, antiviral immune response, acute renal failure, hepatic and heart ischemia/reperfusion injury. On the one hand, it could be found the appropriate drugs to promote ferroptosis to clear cancer cells and virus infected cells, etc. On the other hand, we could inhibit ferroptosis to protect healthy cells. China has a wealth of traditional Chinese medicine resources. Chinese medicine contains a variety of active ingredients that regulate ferroptosis. Here, this paper reported the research of ferroptosis pathway, targets of its inducers and inhibitors that have been discovered, and the regulatory effects of the discovered Chinese herbs and its active ingredients on ferroptosis to help clinical and scientific research.
