Preparation and quality evaluation of volatile oil from Acori Tatarinowii Rhizoma self-nanoemulsion.
10.19540/j.cnki.cjcmm.20180726.016
- Author:
Rui-Na ZHONG
1
;
Xiao-Han WANG
1
;
Xin-Tong WANG
2
;
Bao-de SHEN
2
;
Cheng-Ying SHEN
2
;
Jing WANG
1
;
Li HAN
1
;
Hai-Long YUAN
2
Author Information
1. College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
2. Department of Pharmacy, Air Force General Hospital, PLA, Beijing 100142, China.
- Publication Type:Journal Article
- Keywords:
Box-Behnken response surface methodology;
pseudo-ternary phase diagram;
quality evaluation;
self-nanoemulsion;
volatile oil from Acori Tatarinowii Rhizoma
- MeSH:
Acorus;
chemistry;
Emulsions;
Oils, Volatile;
analysis;
standards;
Particle Size;
Plant Oils;
analysis;
standards;
Rhizome;
chemistry;
Solubility
- From:
China Journal of Chinese Materia Medica
2018;43(20):4062-4068
- CountryChina
- Language:Chinese
-
Abstract:
In order to increase the solubility of volatile oil from Acori Tatarinowii Rhizoma, this study was to prepare self-nanoemulsion of volatile oil from Acori Tatarinowii Rhizoma . The prescriptions were preliminarily screened by miscibility studies, excipient compatibility tests, and pseudo-ternary phase diagrams, and then the optimal formulation was obtained by using the Box-Behnken response surface method, with particle size and drug-loading rate as the indicators. The self-nanoemulsion prepared by optimal prescription was characterized and evaluated for dissolution. The results showed that the optimal prescription for this volatile oil self-nanoemulsion was as follows: 41.7% volatile oil, 46.8% Tween-80, and 11.5% PEG-400. The prepared self-nanoemulsion was clear and transparent, with drug-loading of (192.77±1.64) mg·g⁻¹, particle diameter of (53.20±0.94) nm, polydispersity index of 0.230± 0.013, and Zeta potential of (-12.2±0.7) mV. The dissolution of self-nanoemulsion was higher than that of volatile oil. In this research, volatile oil served as the oil phase in self-nanoemulsion, so the prescription was simpler and the drug loading rate was higher. The prepared self-nanoemulsion complied with the relevant quality requirements, providing a reference for the preparation of volatile oil formulations.
