A new isobenzofuranone derivative from Phlomis betonicoides and its antibacterial activity.

Author: Ping LI ¹ ; Jing LI ² ; Chun-Bo LIU ² ; Jin WANG ² ; Xin LIU ² ; Yan-Ping LI ¹ ; Guang-Yu YANG ² ; Feng-Mei ZHANG ¹ ; Qiu-Fen HU ¹
Author Information

1. College of Chinese National Medicine, Yunnan Minzu University, Kunming 650500, China.
2. Technology Center, China Tobacco Yunnan industrial Co., Ltd., Kunming 650106, China.
Publication Type:Journal Article
Keywords: Phlomis betonicoides; antibacterial activity; isobenzofuranone
MeSH: Anti-Bacterial Agents; isolation & purification; pharmacology; Benzofurans; isolation & purification; pharmacology; Methicillin-Resistant Staphylococcus aureus; drug effects; Microbial Sensitivity Tests; Phlomis; chemistry; Phytochemicals; isolation & purification; pharmacology
From: China Journal of Chinese Materia Medica 2018;43(20):4074-4076
CountryChina
Language:Chinese
Abstract: A new isobenzofuranone derivative has been isolated from Phlomis betonicoides by using various chromatographic techniques, including silica gel, Sephadex LH-20, MCI-gel resin and RP-HPLC. This compound was determined as 5-(3-hydroxypropyl)-2,2-dimethyl-2-furo[3,4-]chromen-7(9)-one (1) by NMR, MS, IR and UV spectroscopic data. Compound 1 showed potent antibacterial activity with an MIC₉₀ value of (58.4 ± 4.2) mg·L⁻¹ for methicillin resistant Staphylococcus aureus (MRSA) strain [levofloxacin as a control with MIC₉₀ value of (52.8±4.6) mg·L⁻¹].