Study on fragmentation pathways of three ginkgolides by mass spectrometry.
10.19540/j.cnki.cjcmm.2018.0108
- Author:
Cong ZHANG
1
;
Jian-Xun LIU
1
;
Ming-Qian SUN
1
;
Lan MIAN
1
;
Lei SUN
1
Author Information
1. Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Pharmacology of Chinese Materia Medica, Beijing 100091, China.
- Publication Type:Journal Article
- Keywords:
fragmentation pathways;
ginkgolides A;
ginkgolides B;
ginkgolides C
- MeSH:
Ginkgolides;
chemistry;
Mass Spectrometry;
Spectrometry, Mass, Electrospray Ionization
- From:
China Journal of Chinese Materia Medica
2018;43(20):4093-4096
- CountryChina
- Language:Chinese
-
Abstract:
The fragmentation pathways of the three ginkgolides (ginkgolides A, ginkgolides B, ginkgolides C) have been studied with high resolution and high mass accuracy using quadrupole time-of-flight mass spectrometry in negative ion mode in this paper. The results indicate that the three ginkgolides have similar fragmentation pathways, including four kinds of common cleavage pathways and one common characteristic ion. In high quality regions, the typical fragmentation pathways of the three ginkgolides are lactone ring opening with continuous loss of CO, CO₂,and loss of H₂O. In low quality regions, the common characteristic fragment ion of the three ginkgolides at 72.993 6 is formed by C rings cleavage. Also, the common fragment ions of ginkgolides A and ginkgolides B at 141.018 8, 125.023 8, 113.024 0, 97.029 1 are formed by A rings cleavage. The study of fragmentation pathways could be adopted for the structural identification of the ginkgolides and their metabolites.
