Study on mechanism of Drynariae Rhizoma in treating osteoporosis with integrative pharmacology perspective.
10.19540/j.cnki.cjcmm.20180508.002
- Author:
Yi-Li ZHANG
1
;
Bin TANG
2
;
Jun-Jie JIANG
1
;
Hao SHEN
3
;
Yan-Ming XIE
1
;
Xu WEI
4
Author Information
1. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
2. Beijing University of Chinese Medicine, Beijing 100029, China.
3. Changxindian Community Health Service Center, Beijing 100072, China.
4. Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China.
- Publication Type:Journal Article
- Keywords:
Drynariae Rhizoma;
integrative pharmacology;
osteoporosis;
signaling pathway;
targets
- MeSH:
Drugs, Chinese Herbal;
pharmacology;
Humans;
Osteoporosis;
drug therapy;
Polypodiaceae;
chemistry;
Receptor, Parathyroid Hormone, Type 1;
metabolism;
Receptor, Parathyroid Hormone, Type 2;
metabolism;
Receptors, Calcitonin;
metabolism;
Rhizome;
chemistry;
Spectrin;
metabolism
- From:
China Journal of Chinese Materia Medica
2018;43(20):4125-4131
- CountryChina
- Language:Chinese
-
Abstract:
Drynariae Rhizoma has great significance in the clinical practice of osteoporosis treatment. Based on the perspective of integrative pharmacology, the study explored the mechanism of action of Drynariae Rhizoma in the treatment of osteoporosis. Six active components in Drynariae Rhizoma were obtained, mainly including glycosides and sterols. Taking the median of 2 times of "node connectivity" as the card value, the core node of the Chinese medicine target disease gene interaction network was selected. Based on this, three topological structural eigenvalues, such as "node connectivity" "node tightness" and "node connectivity" were calculated, thereby screening out four core targets of Drynariae Rhizoma treatment for osteoporosis, including thyroid parathyroid hormone 1 receptor (PTH1R), parathyroid hormone 2 receptor (PTH2R), calcitonin receptor gene (CALCR), and SPTBN1 gene (SPTBN1). Based on the gene ontology database GO and KEGG pathway database, the molecular function, intracellular localization, and biological reactions and pathways of proteins encoded by drug target genes were determined. Combined with enrichment calculation, it is predicted that osteoporosis may play a role in biosynthetic processes, such as circulatory system, nervous system, energy metabolism, prolactin signal pathway, GnRH signaling pathway, neurotrophic factor signaling pathway and other pathway. The conclusion of this study is certain with the existing research results, and the new target and new pathway could also be used as a theoretical basis for the further verification of osteoporosis.
