Application of metabolomics and related technologies in research and development field of traditional Chinese medicine.
10.19540/j.cnki.cjcmm.20180709.005
- Author:
Shang LYU
1
;
Shi-Lin YANG
1
;
Yi RAO
2
;
Yu-Lin FENG
2
Author Information
1. Jiangxi University of Traditional Chinese Medicine, Nanchang 330000, China.
2. National Pharmaceutical Engineering Center for Preparation of Chinese Herbal Medicine, Nanchang 330006, China.
- Publication Type:Journal Article
- Keywords:
analysis technics;
data processing method;
examples of research;
metabolomics;
traditional Chinese medicine
- MeSH:
Computational Biology;
Humans;
Medicine, Chinese Traditional;
Metabolomics;
Research;
trends
- From:
China Journal of Chinese Materia Medica
2018;43(21):4182-4191
- CountryChina
- Language:Chinese
-
Abstract:
Internal environment of metabolism of traditional Chinese medicine (TCM) is a dynamic process, which is in line with the "holistic-dynamic-comprehensive-analytic" characteristics of metabonomics, therefore metabonomics have a unique advantage to reveal the metabolic pattern of TCM. The application of metabonomics in TCM has great practical significance in understanding the pharmacodynamic/toxic effect material basis, mechanisms and guiding for determination of dosage and treatment course; At the same time, the scientific compatibility of TCM prescription, the germplasm resources of TCM and the preclinical safety/toxicity can be widely researched. At present, metabolomics has become a leading technology in many industries and fields including the research and development of TCM. The core of metabolomics is analytical technology, because comprehensive metabolite profiles or accurate identification of known metabolites can be obtained from complex biological samples only by appropriate analytical techniques. At the same time, a series of bioinformatics/chemical informatics/stoichiometry methods are needed to process the data, so as to obtain the potential law and information in the mass data. In this paper, the concept of metabolomics, relevant analytical techniques, data processing methods and applications were explained and analyzed clearly. In addition, the core problems and countermeasures of metabolomics were summarized, and the future development of metabolomics was prospected as well.
