Retrospective analysis and discussion on 74 cases of adverse reactions of traditional Chinese medicine injection.
10.19540/j.cnki.cjcmm.20180815.004
- Author:
Yan WANG
1
;
Li-Ping FAN
1
;
Ju SONG
2
;
Yue-Ping CAI
1
;
Ting-Ting JINANG
1
;
Yu-Guang WANG
1
;
Xiang-Wen KONG
1
;
Jia-Rui WU
3
Author Information
1. Department of Pharmacy, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, China.
2. Office of Pharmaceutical Science of Traditional Chinese Medicine and Ethno-Medicines, Center for Drug Evaluation, China Food and Drug Administration, Beijing 100022, China.
3. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China.
- Publication Type:Journal Article
- Keywords:
adverse drug reaction(ADR);
reason;
retrospective analysis;
traditional Chinese medicine(TCM) injection
- MeSH:
Drugs, Chinese Herbal;
adverse effects;
Female;
Humans;
Injections;
adverse effects;
Male;
Medicine, Chinese Traditional;
adverse effects;
Middle Aged;
Retrospective Studies
- From:
China Journal of Chinese Materia Medica
2018;43(21):4347-4351
- CountryChina
- Language:Chinese
-
Abstract:
As a modern dosage form drug with rapid effect, traditional Chinese medicine (TCM) injection has been more and more used in clinical practice. Meanwhile the safety of TCM injection has attracted more and more attention. The retrospective analysis on 74 cases of adverse reaction of TCM injections collected from 2007 to 2016 in the Third Affiliated Hospital of Beijing University of Chinese Medicine showed that the proportion of men and women with adverse reactions was 0.54:1; the average age was 62.5 years old; 21 kinds of TCM injections were involved. Among them, the most reported were blood-regulating agents. The top four kinds of TCM injections with highest adverse drug reactions (ADRs) were Tanreqing injection, Danhong Injection, Shuxuening Injection and Xuesaitong for injection. The top three clinical manifestations of adverse reactions were lesions of skin and its appendages, damage of circulatory system and damage of nervous system. The potential causes of the adverse reactions of TCM injections were analyzed, and it was believed that individual difference, medicine, pharmaceutical excipients, solvent and TCM syndrome differentiation may be the main five causes for the adverse reactions of TCM injections. In order to reduce the adverse reactions of TCM injections, it is suggested that the clinical pharmacists should participate in the application management of TCM injections in the hospital; the production enterprises shall strengthen the whole life cycle management of the drugs; and at the same time, the drug control and administration authorities should improve the drug management methods constantly and encourage the development of TCM injections to the high quality level.
