Chemical constituents from roots and rhizomes of Rubia oncotricha and their cytotoxic activities.
10.19540/j.cnki.cjcmm.2018.0119
- Author:
Zhe WANG
1
;
Si-Meng ZHAO
2
;
Guang-Zhi ZENG
2
;
Ning-Hua TAN
1
Author Information
1. School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
- Publication Type:Journal Article
- Keywords:
Rubia oncotricha;
cytotoxicity;
quinones;
rubiprasin D;
triterpenes
- MeSH:
Molecular Structure;
Naphthoquinones;
Plant Extracts;
Plant Roots;
Rhizome;
Rubia
- From:
China Journal of Chinese Materia Medica
2018;43(22):4462-4468
- CountryChina
- Language:Chinese
-
Abstract:
Fourteen compounds, including rubiprasin D (1), rubiprasin B (2), rubiprasin C (3), oleanolic acid (4), methyl-5-hydroxy-dinaphtho[1, 2-2'3']furan-7, 12-dione-6-carboxylate (5), rubioncolin C (6), mollugin (7), furomollugin (8), 3-amino-2-methoxycarbonyl-1, 4-naphthoquinone (9), 1-hydroxy-2-methyl-9, 10-anthraquinone (10), 2-hydroxy-6-methyl-9, 10-anthraquinone (11), 1, 4-dihydroxy-2-hydroxymethyl-9, 10-anthraquinone (12), 2-hydroxy-1-methoxy-9, 10-anthraquinone (13), and 1-hydroxy-2-methoxy-6-methyl-9, 10-anthraquinone(14), were isolated from the methanol extract of the roots and rhizomes of Rubia oncotricha using various column chromatographies. Their structures were mainly determined on basis of NMR and MS spectroscopic data analyses. Among them, 1 is a new oleanane triterpene, and compounds 2-5, 9 and 11-13 were obtained from this plant for the first time. Cytotoxic and nematicidal activities of all these compounds were evaluated, and the results showed that only 4, 6, 11 and 12 exhibited cytotoxicities against A549, SGC-7901 and HeLa cancer cell lines. The IC₅₀ of 6 were 19.42, 2.74, 8.07 μmol·L⁻¹, respectively.
