Roles of astrocytes in cerebral infarction and related therapeutic strategies.
- Author:
Jianyu YE
1
;
Ziyu SUN
1
;
Weiwei HU
2
Author Information
1. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
2. Department of Pharmacology, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Astrocytes;
Cerebral Infarction;
physiopathology;
therapy;
Humans;
Neuroglia;
pathology;
Signal Transduction
- From:
Journal of Zhejiang University. Medical sciences
2018;47(5):493-498
- CountryChina
- Language:Chinese
-
Abstract:
Astrocytes are the most abundant cells in the central nervous system and play significant roles in normal brain. With cerebral infarction, astrocytes are activated as reactive astrocytes and form glial scars, which play an essential part in brain injury. According to their roles in neuroprotection after cerebral infarction, regulation of scar formation, nerve regeneration, maintenance of blood-brain barrier, promotion of angiogenesis and immune response, scholars have proposed a variety of therapeutic strategies based on targeting astrocytes. This article reviews the research progress on the changes in astrocyte signaling pathways before and after cerebral infarction and the related therapeutic strategies.
