Roles of CCAAT enhancer binding protein α in acute myeloblastic leukemia.
- Author:
Ting SHI
1
;
Xiujin YE
1
Author Information
1. Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
- Publication Type:Journal Article
- MeSH:
CCAAT-Enhancer-Binding Protein-alpha;
metabolism;
Gene Expression Regulation, Neoplastic;
Hematopoiesis;
genetics;
Humans;
Leukemia, Myeloid, Acute;
physiopathology
- From:
Journal of Zhejiang University. Medical sciences
2018;47(5):552-557
- CountryChina
- Language:Chinese
-
Abstract:
The CCAAT enhancer binding protein α (C/EBP α:p42 and p30),which encoded by CCAAT enhancer binding protein α () gene,plays a pretty crucial role in the regulation of myeloid hematopoiesis.The disorder of CEBPA gene expression is an pivotal mechanism of acute myeloid leukemia (AML). The result of uncontrolled expression of C/EBP α gene is the over-expression of p30 and the incomplete loss of p42, both of which contribute to the occurrence of AML. Restoring the expression ratio of C/EBP α such as over-expression of p42 or blocking the carcinogenic pathway of p30 seems to be important for the treatment of AML caused by such causes. In order to better guide medical decision-making, this article reviews research progress on C/EBPα in the pathogenesis of AML.
