Progress on cancer associated fibroblasts in tumor immunoregulation.
- Author:
Gaopeng LI
1
;
Jia HE
1
;
Qingqing WANG
1
Author Information
1. Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Cancer-Associated Fibroblasts;
Extracellular Matrix;
immunology;
Humans;
Neoplasms;
immunology;
physiopathology;
Tumor Microenvironment;
immunology
- From:
Journal of Zhejiang University. Medical sciences
2018;47(5):558-563
- CountryChina
- Language:Chinese
-
Abstract:
Cancer associated fibroblasts (CAFs) are important components of the tumor microenvironment. Through secreting of multiple growth factors, cytokines and proteases, CAFs play a significant role in regulating the recruitment and function of various innate immune cells and adaptive immune cells in tumor microenvironment. In addition, extracellular matrix secreted by CAFs can also promote the formation of immunosuppression and hypoxia of tumor microenvironment. Here, we review the progress on CAFs in regulation of immune cells and tumor immunity.
