Graft failure in allogeneic hematopoietic stem cell trans-plantation.
- Author:
Liqin CAO
1
;
Jimin SHI
1
Author Information
1. Center of Bone Marrow Transplantation, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
- Publication Type:Journal Article
- MeSH:
Graft vs Host Disease;
epidemiology;
Hematopoietic Stem Cell Transplantation;
statistics & numerical data;
Humans;
Risk Factors;
Transplantation Conditioning;
Transplantation, Homologous;
standards;
statistics & numerical data
- From:
Journal of Zhejiang University. Medical sciences
2018;47(6):651-658
- CountryChina
- Language:Chinese
-
Abstract:
With the progress of medical technology, the development of new drugs and the improvement of the therapeutic effect of graft-versus host disease in the last two decades, the outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) have been greatly improved. However, graft failure is still a rare but serious complication of allo-HSCT. HLA incompatibility, virus infection, elderly donor, uncontrolled primary disease, damage of bone marrow hematopoietic microenvironment, ABO blood group incompatibility, T cell depletion, reduced intensity conditioning, and low nucleated cell number are all risk factors for graft failure. In recent years, with the implementation of HLA haplo-identical hematopoietic stem cell transplantation, the role of donor-specific antibodies in graft failure has attracted attention increasingly. This article reviews the recent studies involving the mechanism, risk factors and prevention measures of graft failure in allo-HSCT.
