Progress on structural biology of voltage-gated ion channels.
- Author:
Fangjun SONG
1
;
Jiangtao GUO
1
Author Information
1. 1. Department of Biophysics, Zhejiang University School of Medicine, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Ion Channel Gating;
physiology;
Ion Channels;
Voltage-Gated Sodium Channels;
chemistry;
metabolism
- From:
Journal of Zhejiang University. Medical sciences
2019;48(1):25-33
- CountryChina
- Language:Chinese
-
Abstract:
Ion channels mediate ion transport across membranes, and play vital roles in processes of matter exchange, energy transfer and signal transduction in living organisms. Recently, structural studies of ion channels have greatly advanced our understanding of their ion selectivity and gating mechanisms. Structural studies of voltage-gated potassium channels elucidate the structural basis for potassium selectivity and voltage-gating mechanism; structural studies of voltage-gated sodium channels reveal their slow and fast inactivation mechanisms; and structural studies of transient receptor potential (TRP) channels provide complex and diverse structures of TRP channels, and their ligand gating mechanisms. In the article we summarize recent progress on ion channel structural biology, and outlook the prospect of ion channel structural biology in the future.
