Application of mechanosensitive channels in sonogenetics.
- Author:
Feifan HONG
1
;
Yuezhou LI
1
Author Information
1. 1. Department of Biophysics, Zhejiang University School of Medicine, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Biomechanical Phenomena;
Ion Channels;
metabolism;
Neurons;
Ultrasonic Waves
- From:
Journal of Zhejiang University. Medical sciences
2019;48(1):34-38
- CountryChina
- Language:Chinese
-
Abstract:
As a non-invasive approach, sonogenetics is applied to control neuronal activity. The mechanosensitive channel(MSC), which has low threshold of responding to ultrasound, may be the alternative solution. Sonogenetics is the technique that activates the MSC expressed in targeted neurons by low intensity ultrasound, thus achieve the neuromodulation. In this review, we introduce the mechanosensitive channel of large conductance, transient receptor potential, channels of the two-pore-domain potassium family, Piezo and the recent progress on their application in sonogenetics.
