Progress on correlation between cell senescence and idiopathic pulmonary fibrosis.
- Author:
Shihao ZHAO
1
;
Xue ZHANG
1
;
Yuehai KE
1
Author Information
1. College of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Autophagy;
Cellular Senescence;
Epigenesis, Genetic;
Gene Expression;
Humans;
Idiopathic Pulmonary Fibrosis;
physiopathology
- From:
Journal of Zhejiang University. Medical sciences
2019;48(1):111-115
- CountryChina
- Language:Chinese
-
Abstract:
Cellular senescence is a key factor driving age-related diseases. Recent studies have revealed that senescence-associated secretory phenotype, telomere attrition, epigenetic changes, and mitochondrial autophagy damage may mediate the pathogenesis of senescence-related idiopathic pulmonary fibrosis (IPF). Reducing the level of cellular senescence or clearing senescent cells can down-regulate the expression of fibrosis factors and alleviate the symptoms of IPF. In this review, we outlined the role and mechanism of cellular senescence in IPF.
