Research advances on the role of exosomes in chemotherapy resistance of ovarian cancer.
- Author:
Xiameng SHEN
1
;
Weiguo LYU
1
Author Information
1. Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents;
therapeutic use;
Carcinoma, Ovarian Epithelial;
drug therapy;
physiopathology;
Drug Resistance, Neoplasm;
Exosomes;
metabolism;
Female;
Humans;
Ovarian Neoplasms;
drug therapy;
physiopathology
- From:
Journal of Zhejiang University. Medical sciences
2019;48(1):116-120
- CountryChina
- Language:Chinese
-
Abstract:
Chemotherapy resistance is one of the biggest challenges in treatment of ovarian cancer. Mounting evidence shows that the exosomes shedding from tumor cells are considered to be involved in chemotherapy resistance of ovarian cancer by enhanced exosomal export of drugs, transferring RNAs or proteins and interfering with the bioactivity of therapeutic anti-tumor antibodies. In this review, we display the correlation between exosomes and chemotherapy resistance of ovarian cancer, the mechanism of exosomes involved in chemotherapy resistance of ovarian cancer, and discuss the potential clinical values of exosomes in chemotherapy resistance of ovarian cancer.
