Roles of macrophages in formation and progression of intracranial aneurysms.
- Author:
Yaqi WANG
1
;
Jinghua JIN
1
Author Information
1. Department of Neurobiology, Zhejiang University School of Medicine, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Cytokines;
Disease Progression;
Humans;
Inflammation;
Intracranial Aneurysm;
complications;
drug therapy;
pathology;
Macrophages;
metabolism
- From:
Journal of Zhejiang University. Medical sciences
2019;48(2):204-213
- CountryChina
- Language:Chinese
-
Abstract:
Studies have shown that chronic inflammatory response plays a key role in intracranial aneurysms (IA) formation and progression, and macrophages regulate the formation and progression of IA through a variety of pathways. Bone marrow monocyte-derived macrophages and resident-tissue macrophages infiltrate the vessel wall, after infiltration macrophages are polarized into various polarization phenotypes dominated by M1-like and M2-like cells. Polarized phenotypes of macrophages can regulate the formation and progression of intracranial aneurysms by releasing cytokines and regulating the inflammatory response of other immune cells, as well as release different cytokines to regulate the process of extracellular matrix remodeling. Some important progresses have been made in the clinical detection and treatment in targeting macrophages. This review provides a summary on the pathogenesis of IA and potential drug targets to prevent the formation and rupture of intracranial aneurysms.
