Effects of aerobic glycolysis on pathogenesis and drug resistance of non-Hodgkin lymphoma.
- Author:
Li XU
1
;
Ming XU
2
;
Xiangmin TONG
3
Author Information
1. Department of Oncology, the First People's Hospital of Tongxiang, Tongxiang 314500, Zhejiang Province, China.
2. Department of Traditional Chinese Medicine, the First People's Hospital of Tongxiang, Tongxiang 314500, Zhejiang Province, China.
3. Department of Hematology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China.
- Publication Type:Journal Article
- MeSH:
Drug Resistance, Neoplasm;
Glycolysis;
Humans;
Lymphoma, Non-Hodgkin;
physiopathology;
Signal Transduction
- From:
Journal of Zhejiang University. Medical sciences
2019;48(2):219-223
- CountryChina
- Language:Chinese
-
Abstract:
It has been shown that aerobic glycolysis (AG) plays an important role in the pathogenesis and resistance mechanism of non-Hodgkin lymphoma (NHL) in recent years. Signaling pathway related to abnormal activation of AG can increase the level of AG in lymphatic and hematopoietic cells, while the enzymes related to the activity of AG are involved in the pathogenesis and prognosis of NHL. Drugs that inhibit AG can also inhibit NHL cells . Drugs inhibiting AG may increase the sensitivity of chemotherapeutic agents and prevent drug resistance. In this article, the role of signaling pathway proteins and regulatory genes related to AG in the pathogenesis and drug resistance of NHL are reviewed, and the AG as a target in the clinical diagnosis and treatment of NHL is discussed.
