Association of atrial fibrillation with hemorrhagic transformation after intravenous thrombolysis in patients with ischemic stroke.
- Author:
Anyang TAO
1
;
Zhimin WANG
1
;
Hongfang CHEN
2
;
Dongjuan XU
3
;
Haifang HU
4
;
Chenglong WU
5
;
Xiaoling ZHANG
6
;
Xiaodong MA
7
;
Yaxian WANG
8
;
Haitao HU
9
;
Min LOU
9
Author Information
1. Department of Neurology, Taizhou First People's Hospital, Taizhou 318020, Zhejiang Province, China.
2. Department of Neurology, Jinhua Hospital of Zhejiang University, Jinhua Municipal Central Hospital, Jinhua 321000, Zhejiang Province, China.
3. Department of Neurology, Dongyang People's Hospital, Dongyang 322100, Zhejiang Province, China.
4. Department of Neurology, the First People's Hospital of Xiaoshan District, Hangzhou 311201, China.
5. Department of Neurology, Shaoxing People's Hospital, Shaoxing 312000, Zhejiang Province, China.
6. Department of Neurology, Jiaxing Second Hospital, Jiaxing 314000, Zhejiang Province, China.
7. Department of Neurology, Haiyan People's Hospital, Haiyan 314300, Zhejiang Province, China.
8. Department of Neurology, Huzhou Central Hospital, Huzhou 313003, Zhejiang Province, China.
9. Department of Neurology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
- Publication Type:Journal Article
- MeSH:
Antifibrinolytic Agents;
adverse effects;
pharmacology;
Atrial Fibrillation;
complications;
Brain Ischemia;
complications;
drug therapy;
Humans;
Retrospective Studies;
Stroke;
complications;
drug therapy;
Thrombolytic Therapy;
adverse effects;
Treatment Outcome
- From:
Journal of Zhejiang University. Medical sciences
2019;48(3):254-259
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the association of atrial fibrillation (AF) with hemorrhagic transformation (HT) in patients with ischemic stroke treated by intravenous thrombolysis.
METHODS:Clinical data of 3272 patients treated by intravenous thrombolysis from 71 hospitals in Zhejiang Province during June 2017 and December 2018 were retrospectively reviewed. Intracranial HT was defined as intracranial hemorrhage suggested by imaging examination 24 hours after intravenous thrombolysis. Patients were dichotomized into HT group (=533) and non-HT group (=2739). The association of AF and HT was analyzed by univariate analysis and binary logistic regression.
RESULTS:Compared with the non-HT group, the HT group were older, had longer onset to needle time (ONT), higher baseline National Institute of Health Stroke Scale (NIHSS) score, higher baseline glucose level, and higher AF rate (<0.05 or <0.01). Binary logistic regression analysis revealed that AF was independently associated with HT (=2.527, 95%:2.030-3.146, <0.01).
CONCLUSIONS:AF is independently associated with the occurrence of HT in ischemic stroke patients treated with intravenous thrombolysis.
