Analysis of intravenous thrombolysis time and prognosis in patients with in-hospital stroke.
- Author:
Congcong ZHANG
1
;
Min LOU
1
;
Zhicai CHEN
1
;
Hongfang CHEN
2
;
Dongjuan XU
3
;
Zhimin WANG
4
;
Haifang HU
5
;
Chenglong WU
6
;
Xiaoling ZHANG
7
;
Xiaodong MA
8
;
Yaxian WANG
9
;
Haitao HU
1
Author Information
1. Department of Neurology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
2. Department of Neurology, Jinhua Hospital of Zhejiang University, Jinhua Municipal Central Hospital, Jinhua 321000, Zhejiang Province, China.
3. Department of Neurology, Dongyang People's Hospital, Dongyang 322100, Zhejiang Province, China.
4. Department of Neurology, Taizhou First People's Hospital, Taizhou 318020, Zhejiang Province, China.
5. Department of Neurology, the First People's Hospital of Xiaoshan District, Hangzhou 311201, China.
6. Department of Neurology, Shaoxing People's Hospital, Shaoxing 312000, Zhejiang Province, China.
7. Department of Neurology, Jiaxing Second Hospital, Jiaxing 314000, Zhejiang Province, China.
8. Department of Neurology, Haiyan People's Hospital, Haiyan 314300, Zhejiang Province, China.
9. Department of Neurology, Huzhou Central Hospital, Huzhou 313003, Zhejiang Province, China.
- Publication Type:Journal Article
- MeSH:
Administration, Intravenous;
Brain Ischemia;
drug therapy;
Fibrinolytic Agents;
therapeutic use;
Hospitals;
statistics & numerical data;
Humans;
Prognosis;
Stroke;
drug therapy;
Thrombolytic Therapy;
statistics & numerical data;
Time Factors;
Treatment Outcome
- From:
Journal of Zhejiang University. Medical sciences
2019;48(3):260-266
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the time delay between in-hospital stroke and out-of-hospital stroke patients, and to explore the influence factors for the prognosis of in-hospital stroke patients treated by intravenous thrombolysis.
METHODS:Clinical data of 3050 patients with ischemic stroke who received intravenous thrombolysis in 71 hospitals in Zhejiang province from June 2017 to September 2018 were analyzed. Differences of time delay including door to imaging time (DIT), imaging to needle time (INT) and door to needle time (DNT) between in-hospital stroke (=101) and out-of-hospital stroke (=2949) were observed. The influencing factors for the outcome at 3 month after intravenous thrombolysis in patients with in-hospital stroke were analyzed using binary logistic regression analysis.
RESULTS:Patients with in-hospital stroke had longer DIT[53.5 (32.0-79.8) min vs. 20.0 (14.0-28.0) min, <0.01], longer IDT[47.5(27.3-64.0)min vs. 36.0(24.0-53.0)min, <0.01], and longer DNT[99.0 (70.5-140.5) min vs. 55.0 (41.0-74.0) min, <0.01], compared with patients with out-of-hospital stroke; patients in comprehensive stroke center had longer DIT[59.5(44.5-83.3) min vs. 37.5(16.5-63.5) min, <0.01], longer DNT[110.0(77.0-145.0) min vs. 88.0 (53.8-124.3) min, <0.05], but shorter INT[36.5(23.8-60.3)min vs. 53.5 (34.3-64.8) min, <0.05], compared with patients in primary stroke center. Age (=0.934, 95% 0.882-0.989, <0.05) and baseline National Institute of Health Stroke Scale score (=0.912, 95% 0.855-0.973, <0.01) were independent risk factors for prognosis of in-hospital stroke patients.
CONCLUSIONS:In-hospital stroke had longer DIT and DNT than out-of-hospital stroke, which suggests that a more smooth thrombolysis process of in-hospital stroke should be established.
