Nucleus translocation of membrane/cytoplasm proteins in tumor cells.
- Author:
Ziling ZHU
1
;
Jing TAN
1
;
Hong DENG
1
Author Information
1. Zhejiang Key Laboratory for Disease Proteomics, Department of Pathology, Zhejiang University School of Medicine, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Carcinogenesis;
pathology;
Cell Line, Tumor;
Cell Nucleus;
metabolism;
Cytoplasm;
metabolism;
Gene Expression Regulation, Neoplastic;
Humans;
Membrane Proteins;
metabolism;
Protein Domains;
Protein Transport;
physiology;
Signal Transduction
- From:
Journal of Zhejiang University. Medical sciences
2019;48(3):318-325
- CountryChina
- Language:Chinese
-
Abstract:
Proteins are the physical basis of life and perform all kinds of life activities. Proteins have different orientations and function in different tissues. The same protein, located in different subcellular regions, can perform different and even opposite functions. Both functional and structural proteins are capable of undergoing re-localization which can directly or indirectly participate in signal transduction. Due to abnormal transduction of signals during carcinogenesis, the proteins originally expressed in the cytoplasm are translocated into the nucleus and lead to functional changes in the tumor tissue. The changes of protein localization are affected by many factors, including the interaction between proteins, expression level of proteins and the cleaved intracellular domain of transmembrane protein.
