Association of Ureaplasma urealyticum with the types of antisperm antibody in infertile men.
- Author:
Zhen-Cheng ZHANG
1
;
Mu-Tian HAN
2
;
Wen-Jun WU
1
;
Gai-Gai WANG
2
;
Dong-Hong LIU
1
;
Hong-Bo CHENG
2
;
Jia-Xiong WANG
2
;
Li-Yan SHEN
2
;
Yi-Chao SHI
2
Author Information
1. Department of Clinical Laboratory, Taizhou First People's Hospital, Taizhou, Zhejiang 318000, China.
2. Center of Reproductive Medicine, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou, Jiangsu 215002, China.
- Publication Type:Journal Article
- Keywords:
IgA;
IgG;
IgM;
Ureaplasma urealyticum;
antisperm antibody;
semen parameter;
male infertility
- MeSH:
Antibodies, Bacterial;
analysis;
Humans;
Infertility, Male;
immunology;
microbiology;
Male;
Semen;
Sperm Count;
Spermatozoa;
immunology;
Ureaplasma Infections;
diagnosis;
immunology;
Ureaplasma urealyticum;
immunology
- From:
National Journal of Andrology
2018;24(2):147-151
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the prevalence of Ureaplasma urealyticum (UU) infection in infertile men, its influence on routine semen parameters and the distribution of antisperm antibody (AsAb) and its types in infertile patients with UU infection.
METHODS:We detected the positive rate of UU infection, semen parameters, and the distribution of AsAb and its types in 662 infertile men and 25 normal fertile male controls followed by comparison of the obtained data between the two groups of subjects.
RESULTS:The positive rate of UU infection was significantly higher in the infertile men than in the normal controls (52.87% ［350/662］ vs 16.00% ［4/25］, χ2 = 11.68, P <0.05). The semen volume, sperm count, sperm concentration and percentage of progressively motile sperm were remarkably lower in the UU-positive infertile males than in the control group (P <0.05). No statistically significant difference was observed between the UU-positive and UU-negative groups in the positive rates of total AsAb (43.4% vs 36.5%, χ2 = 3.25, P >0.05) and AsAb IgA, IgM and IgG in the seminal plasma, or in the percentages of serum AsAb IgM (16.9% vs 20.5%, χ2 = 1.22, P >0.05) and IgG (32.7% vs 28.9%, χ2 = 0.99, P >0.05) except in that of serum AsAb IgA (23.6% vs 17.0%, χ2 = 4.03, P <0.05).
CONCLUSIONS:The UU infection rate is high in infertile males, which decreases the semen volume, total sperm count, motile sperm concentration and percentage of progressively motile sperm and increases the positive rate of serum AsAb IgA.
