Hepatocyte growth factor and carotid intima-media thickness in relation to circulating CD34-positive cell levels.
10.1186/s12199-018-0705-4
- Author:
Yuji SHIMIZU
1
;
Shimpei SATO
2
;
Jun KOYAMATSU
3
;
Hirotomo YAMANASHI
3
;
Mako NAGAYOSHI
2
;
Shin-Ya KAWASHIRI
2
;
Keita INOUE
2
;
Shoichi FUKUI
2
;
Hideaki KONDO
2
;
Seiko NAKAMICHI
4
;
Yasuhiro NAGATA
5
;
Takahiro MAEDA
2
Author Information
1. Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki-shi, Sakamoto 1-12-4, Nagasaki, 852-8523, Japan. shimizuyuji@nagasaki-u.ac.jp.
2. Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki-shi, Sakamoto 1-12-4, Nagasaki, 852-8523, Japan.
3. Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
4. Department of General Medicine, Nagasaki University Hospital, Nagasaki, Japan.
5. Center for Comprehensive Community Care Education, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
- Publication Type:Journal Article
- Keywords:
CD34-positive cell;
CIMT;
Elderly men;
Endothelial repair;
HGF
- MeSH:
Aged;
Antigens, CD34;
blood;
Biomarkers;
blood;
Carotid Intima-Media Thickness;
Cross-Sectional Studies;
Hepatocyte Growth Factor;
metabolism;
Humans;
Japan;
Male;
Middle Aged
- From:Environmental Health and Preventive Medicine
2018;23(1):16-16
- CountryJapan
- Language:English
-
Abstract:
BACKGROUND:Hepatocyte growth factor (HGF) may act as a possible biochemical index for vascular damage, although evidence for the association between HGF and carotid intima-media thickness (CIMT) is limited. Since both HGF and circulating CD34-positive cells play an important role in endothelial repair, circulating CD34-positive cell levels may influence the association between HGF and CIMT.
METHODS:We conducted a cross-sectional study of 269 elderly Japanese men aged 60-69 years who had undertaken an annual medical checkup from 2014 to 2015.
RESULTS:The median value for circulating CD34-positive cells was 0.93 cells/μL. Among the study population, 135 men showed low circulating CD34-positive cell levels (≤ 0.93 cells/μL). By multivariable linear regression analysis, HGF was found to be significantly positively associated with CIMT only to participants with low circulating CD34-positive cell levels, with a multi-adjusted β of 0.26 (p = 0.005) and 0.002 (0.986) for low and high circulating CD34-positive cell levels, respectively. In addition, a significant interaction was observed between HGF and circulating CD34-positive cell levels (low and high) on CIMT (multivariable p value of 0.049). A positive association exists between HGF and CIMT in elderly Japanese men, limited to participants with low circulating CD34-positive cell levels.
CONCLUSION:A positive association exists between HGF and CIMT in community-dwelling elderly Japanese men, which is limited to participants with low numbers of circulating CD34-positive cells. Our findings indicate that circulating CD34-positive cell levels could determine the influence of HGF on CIMT in elderly Japanese men.
