The toxicological mechanisms and detoxification of depleted uranium exposure.
10.1186/s12199-018-0706-3
- Author:
Yong-Chao YUE
1
;
Ming-Hua LI
1
;
Hai-Bo WANG
1
;
Bang-Le ZHANG
2
;
Wei HE
3
Author Information
1. Department of Chemistry, School of Pharmacy, Fourth Military Medical University, No. 169 Changle West Road, Xi'an, 710032, Shaanxi, People's Republic of China.
2. Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, No. 169 Changle West Road, Xi'an, 710032, Shaanxi, People's Republic of China. blezhang@fmmu.edu.cn.
3. Department of Chemistry, School of Pharmacy, Fourth Military Medical University, No. 169 Changle West Road, Xi'an, 710032, Shaanxi, People's Republic of China. weihechem@fmmu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Chelating agents;
Decorporation;
Depleted uranium;
Toxicity
- MeSH:
Animals;
Chelating Agents;
pharmacology;
Humans;
Inactivation, Metabolic;
Radiation-Protective Agents;
pharmacology;
Uranium;
metabolism;
toxicity
- From:Environmental Health and Preventive Medicine
2018;23(1):18-18
- CountryJapan
- Language:English
-
Abstract:
Depleted uranium (DU) has been widely applied in industrial and military activities, and is often obtained from producing fuel for nuclear reactors. DU may be released into the environment, polluting air, soil, and water, and is considered to exert both radiological and chemical toxicity. In humans and animals, DU can induce multiple health effects, such as renal tubular necrosis and bone malignancies. This review summarizes the known information on DU's routes of entry, mechanisms of toxicity, and health effects. In addition, we survey the chelating agents used in ameliorating DU toxicity.
