Evaluation of chemical-specific IgG antibodies in male workers from a urethane foam factory.
10.1186/s12199-018-0713-4
- Author:
Mayumi TSUJI
1
;
Yasuhiro ISHIHARA
2
;
Toyohi ISSE
3
;
Chihaya KORIYAMA
4
;
Megumi YAMAMOTO
5
;
Noriaki KAKIUCHI
6
;
Hsu-Sheng YU
3
;
Masayuki TANAKA
3
;
Takuto TSUCHIYA
3
;
Masanori OHTA
7
;
Rie TANAKA
3
;
Toshihiro KAWAMOTO
3
Author Information
1. Department of Environment Health, University of Occupational and Environmental Health, Kitakyushu, Japan. tsuji@med.uoeh-u.ac.jp.
2. Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashihiroshima, Japan.
3. Department of Environment Health, University of Occupational and Environmental Health, Kitakyushu, Japan.
4. Department of Epidemiology and Preventive Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
5. Department of Environment and Public Health, National Institute for Minamata Disease, Minamata, Japan.
6. Institute of industrial and Ecological Sciences, University of occupational and Environmental Health, Kitakyushu, Japan.
7. Department of Food and Health Sciences, International College of Arts and Sciences, Fukuoka Women's University, Fukuoka, Japan.
- Publication Type:Journal Article
- Keywords:
Chemical-specific IgG antibodies;
Male workers;
Occupational allergy (OA);
Urethane foam factory
- MeSH:
Adult;
Air Pollutants, Occupational;
adverse effects;
immunology;
Environmental Monitoring;
Humans;
Immunoglobulin G;
blood;
immunology;
Japan;
Male;
Manufacturing and Industrial Facilities;
statistics & numerical data;
Middle Aged;
Occupational Diseases;
blood;
chemically induced;
Occupational Exposure;
adverse effects;
statistics & numerical data;
Phthalic Anhydrides;
immunology;
toxicity;
Respiratory Hypersensitivity;
blood;
chemically induced;
Toluene 2,4-Diisocyanate;
immunology;
toxicity;
Workforce
- From:Environmental Health and Preventive Medicine
2018;23(1):24-24
- CountryJapan
- Language:English
-
Abstract:
BACKGROUND:Plastic resins are complex chemicals that contain toluene diisocyanate (TDI) and/or trimellitic anhydride (TMA), which cause occupational allergies (OA), including respiratory allergies. Serum IgGs against TDI and TMA have been suggested as potential markers of the exposure status and as exploring cause of OA. Although TDI-specific IgG has been examined for suspected OA, TMA-specific IgG is not commonly evaluated in a urethane foam factory. This study therefore investigated both TDI- and TMA-specific IgGs in suspected OA patients and to evaluate the usefulness of the measurement of multiple chemical-specific IgG measurement for practical monitoring.
METHODS:Blood samples were collected from two male workers who developed respiratory allergies supposedly caused by occupational exposure to TDI and/or TMA for the presence of TDI- and TMA-specific IgGs. In addition, blood samples from 75 male workers from a urethane foam factory, along with 87 male control subjects, were collected in 2014 and tested for the same IgGs in 2014. The presence and levels of TDI- and TMA-specific serum IgGs were measured using dot blot assays.
RESULTS:We found that controls had mean concentrations of TDI- and TMA-specific IgGs of 0.98 and 2.10 μg/mL, respectively. In the two workers with respiratory allergies, the TDI-specific IgG concentrations were 15.6 and 9.51 μg/mL, and TMA-specific IgG concentrations were 4.56 and 14.4 μg/mL, which are clearly higher than those in controls. Mean concentrations of TDI- and TMA-specific IgGs in the factory workers were 1.89 and 2.41 μg/mL, respectively, and are significantly higher than those of the controls (P < 0.001 and P < 0.026 for TDI- and TMA-specific IgGs, respectively).
CONCLUSION:The workers suspected of OA showed an evidently high level of TDI- and TMA-specific IgG, and these levels in workers at the urethane foam factory were also significantly higher than those in controls. In conclusion, the measurement of TDI- and TMA-specific IgG among workers using plastic resins is helpful to monitor their exposure status.
