Clinical characteristics and drug sensitivity in children with invasive pneumococcal disease: a multicenter study.
- Author:
Cai-Yun WANG
1
;
Ying-Hu CHEN
;
Xue-Jun CHEN
;
Hong-Mei XU
;
Chun-Mei JING
;
Ji-Kui DENG
;
Rui-Zhen ZHAO
;
Hui-Ling DENG
;
San-Cheng CAO
;
Hui YU
;
Chuan-Qing WANG
;
Ai-Min WANG
;
Ai-Wei LIN
;
Shi-Fu WANG
;
Qing CAO
;
Xing WANG
;
Ting ZHANG
;
Hong ZHANG
;
Jian-Hua HAO
;
Cong-Hui ZHANG
Author Information
1. Department of Infectious Disease, Children's Hospital of Zhejiang University School of Medicine, Hangzhou 310052, China. cyh18@zju.edu.cn.
- Publication Type:Journal Article
- MeSH:
Anti-Bacterial Agents;
Ceftriaxone;
Child;
Child, Preschool;
Drug Resistance;
Female;
Humans;
Infant;
Male;
Microbial Sensitivity Tests;
Pneumococcal Infections;
Streptococcus pneumoniae
- From:
Chinese Journal of Contemporary Pediatrics
2019;21(7):644-649
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the clinical characteristics, drug sensitivity of isolated strains, and risk factors of drug resistance in children with invasive pneumococcal disease (IPD).
METHODS:The clinical characteristics and drug sensitivity of the isolated strains of 246 hospitalized children with IPD in nine grade A tertiary children's hospitals from January 2016 to June 2018 were analyzed.
RESULTS:Of the 246 children with IPD, there were 122 males and 124 females. Their ages ranged from 1 day to 14 years, and among them, 68 (27.6%) patients were less than 1 year old, 54 (22.0%) patients were 1 to 2 years old, 97 (39.4%) patients were 2 to 5 years old, and 27 (11.0%) patients were 5 to 14 years old. Pneumonia with sepsis was the most common infection type (58.5%, 144/246), followed by bloodstream infection without focus (19.9%, 49/246) and meningitis (15.0%, 37/246). Forty-nine (19.9%) patients had underlying diseases, and 160 (65.0%) had various risk factors for drug resistance. The isolated Streptococcus pneumoniae strains were 100% sensitive to vancomycin, linezolid, moxifloxacin, and levofloxacin, 90% sensitive to ertapenem, ofloxacin, and ceftriaxone, but had a low sensitivity to erythromycin (4.2%), clindamycin (7.9%), and tetracycline (6.3%).
CONCLUSIONS:IPD is more common in children under 5 years old, especially in those under 2 years old. Some children with IPD have underlying diseases, and most of the patients have various risk factors for drug resistance. Pneumonia with sepsis is the most common infection type. The isolated Streptococcus pneumoniae strains are highly sensitive to vancomycin, linezolid, moxifloxacin, levofloxacin, ertapenem, and ceftriaxone in children with IPD.
