Research advances in the role of mTOR signaling pathway in autism spectrum disorder.
- Author:
Guo-Xia SHENG
1
;
Ke-Wen JIANG
Author Information
1. Department of Neurology, Children's Hospital of Zhejiang University, Hangzhou 310000, China. jiangkw_zju@zju.edu.cn.
- Publication Type:Journal Article
- MeSH:
Animals;
Autism Spectrum Disorder;
Humans;
Signal Transduction;
Sirolimus;
TOR Serine-Threonine Kinases
- From:
Chinese Journal of Contemporary Pediatrics
2019;21(7):718-723
- CountryChina
- Language:Chinese
-
Abstract:
Mammalian target of rapamycin (mTOR) is an intracellular signaling pathway molecule which regulates various fundamental physiological processes. The mTOR signaling pathway plays an important role in synaptic plasticity, information transmission and processing, and neuroregulation. Dysregulation of the mTOR signaling pathway is generally considered to be related to the pathogenesis of autism spectrum disorder (ASD); meanwhile, the mTOR inhibitor can ameliorate the symptoms of ASD. The role of mTOR in the pathogenesis of ASD is summarized in this article to provide a theoretical basis for targeted therapy of ASD.
