Pathogenesis of steroid-resistant asthma and the influence of vitamin D.
- Author:
Yu-Xiao YAN
1
;
Yu-Ning LI
Author Information
1. First Clinical Medical College of Lanzhou University, Lanzhou 730000, China. 13993127126@163.com.
- Publication Type:Journal Article
- MeSH:
Asthma;
Drug Resistance;
Glucocorticoids;
Humans;
Quality of Life;
Receptors, Glucocorticoid;
Vitamin D
- From:
Chinese Journal of Contemporary Pediatrics
2019;21(7):724-729
- CountryChina
- Language:Chinese
-
Abstract:
Glucocorticoid (GC) is currently the most effective drug for controlling persistent asthma; however, there is a significant difference in the response to GC among patients with asthma. Steroid-resistant asthma is one of the subtypes of asthma and has poor response to high-dose GC treatment. It may affect the quality of life of patients and even threaten their lives. Therefore, it is of great significance to explore the pathogenesis of steroid-resistant asthma and related targeted treatment strategy. In recent years, a variety of pathogeneses have been found to participate in the development and progression of steroid-resistant asthma, including the reduction in the binding between GC receptor and GC, the increase in the expression of GC receptor β, over-activation of nuclear transcription factor activating protein 1 and nuclear factor-κB, abnormality in histone acetylation, and immune-mediated cytokine dysregulation. In addition, many studies have shown that vitamin D can improve the sensitivity to GC among patients with steroid-resistant asthma. This article reviews the pathogenesis of steroid-resistant asthma and the influence of vitamin D.
