Anti-Inflammatory Effect of Violapyrones B and C from a Marine-derived Streptomyces sp..
10.20307/nps.2015.21.4.251
- Author:
Hwa Sun LEE
1
;
Bong Jeun AN
;
Hyeon Jeong KIM
;
Yong Hun CHO
;
Dong In KIM
;
Jae Yoon JANG
;
Jae Hoon KWAK
;
Hyi Seung LEE
;
Yeon Ju LEE
;
Jong Seok LEE
;
Hee Jae SHIN
Author Information
1. Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 787 Haeanro, Ansan 426-744, Korea. shinhj@kiost.ac
- Publication Type:In Vitro ; Original Article
- Keywords:
Violapyrones;
alpha-Pyrones;
Streptomyces sp.;
Anti-inflammatory
- MeSH:
Streptomyces*
- From:Natural Product Sciences
2015;21(4):251-254
- CountryRepublic of Korea
- Language:English
-
Abstract:
Recently, we reported violapyrones B, C, H and I, unusual 3, 4, 6-trisubstituted alpha-pyrone derivatives, from the culture broth of the marine Streptomyces sp. 112CH148. In previous studies, violapyrones have been shown to have antibacterial and antitumor activities. However, the anti-inflammatory effect of violapyrones has not been reported yet. As part of our ongoing study for the discovery of bioactive metabolites from marine microorganisms, we found that violapyrones also have anti-inflammatory activity. In this study, we investigated the effect of violapyrones on LPS-induced inflammatory responses in vitro. Violapyrones B and C did not affect the viability of RAW 264.7 cells at concentrations up to 25 microM. However, violapyrones B and C inhibited the production of NO compared to the LPS-induced control. In addition, violapyrones B and C down-regulated the expression of iNOS protein in LPS-stimulated RAW 264.7 cells. To the best of our knowledge, this is the first report on the anti-inflammatory activity of violapyrones B and C.
