Correlation between serum microRNA-122 and insulin resistance in obese children.
- Author:
Qiong CHEN
1
;
Yao-Dong ZHANG
;
Sheng-Nan WU
;
Yong-Xing CHEN
;
Xiao-Jing LIU
;
Hai-Yan WEI
Author Information
1. Department of Endocrinology and Inherited Metabolic Disease, Children's Hospital Affiliated to Zhengzhou University/Henan Children's Hospital/Zhengzhou Children's Hospital, Zhengzhou 450000, China. haiyanwei2009@163.com.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Blood Glucose;
Body Mass Index;
Child;
Humans;
Insulin;
Insulin Resistance;
MicroRNAs;
genetics;
Obesity;
Waist-Hip Ratio
- From:
Chinese Journal of Contemporary Pediatrics
2019;21(9):910-914
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the relationship between serum microRNA-122 (miR-122) and insulin resistance in obese children.
METHODS:Forty-seven children with severely obesity aged 7-14 years and 45 age- and gender matched healthy children with normal weight (control group) were enrolled. The levels of height, weight, waistline, hip circumference, fasting blood glucose (FBG), fasting insulin (FINS), triglyceride (TG), total cholesterol (TC), free fatty acid (FFA), interleukin-6 (IL-6) and miR-122 in the two groups were measured. Body mass index (BMI), waist-hip ratio (WHR) and insulin resistance index (HOMA-IR) were calculated.
RESULTS:Compared with the control group, the height, weight, BMI, WHR, FINS, HOMA-IR, TG, FFA, IL-6, and miR-122 levels in the obese group were significantly increased (P<0.05). MiR-122 levels in the obese group were positively correlated with FINS, HOMA-IR and IL-6 levels (r=0.408, 0.442, and 0.464 respectively, P<0.05). The changes of miR-122 have a linear regression relationship with IL-6 (b'=0.318, P<0.05).
CONCLUSIONS:The elevated serum miR-122 levels may be correlated with insulin resistance in obese children. The mechanism needs to be further studied.
