A clinical analysis of bacterial meningitis in full-term and preterm infants.
- Author:
Xiao-Lin ZHAO
1
;
Jin-Zhen GUO
;
Zhan-Kui LI
Author Information
1. Department of Neonatology, Northwest Women's and Children's Hospital, Xi'an 710061, China. lzk5808@163.com.
- Publication Type:Journal Article
- MeSH:
Apnea;
Humans;
Infant, Newborn;
Infant, Premature;
Leukocyte Count;
Meningitis, Bacterial;
Retrospective Studies
- From:
Chinese Journal of Contemporary Pediatrics
2019;21(10):1044-1048
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the clinical features and prognosis of bacterial meningitis in full-term and preterm infants.
METHODS:A retrospective analysis was performed for the clinical data of 102 neonates with bacterial meningitis. According to the gestational age, they were divided into a preterm group (n=46) and a full-term group (n=56). The two groups were compared in terms of clinical manifestations, laboratory markers, imaging findings, and clinical outcomes.
RESULTS:Poor response and apnea were the major clinical manifestations in the preterm group (P<0.05), while pyrexia and convulsions were more common in the full-term group (P<0.05). The full-term group had a significantly higher glucose level in cerebrospinal fluid (CSF) than the preterm group (P<0.05). Compared with the full-term group, the preterm group had significantly higher C-reactive protein level, positive rate of blood culture, and incidence rate of poor prognosis (P<0.05). There were no significant differences between the two groups in leukocyte count in peripheral blood, levels of leukocytes and protein in CSF, and positive rate of CSF culture (P>0.05).
CONCLUSIONS:There are certain differences in the clinical manifestations between full-term and preterm infants with bacterial meningitis. Preterm infants tend to have a higher incidence rate of poor prognosis.
