Research advances in augmented renal clearance in critically ill children.
- Author:
Ran ZHOU
1
;
Yu-Ting FANG
;
Dan SU
Author Information
1. Department of Life Sciences and Medicine, First Affiliated Hospital of University of Science and Technology of China/Anhui Provincial Hospital, Hefei 230001, China. sudan422@126.com.
- Publication Type:Journal Article
- MeSH:
Anti-Bacterial Agents;
Child;
Creatinine;
Critical Illness;
Humans;
Kidney Function Tests;
Risk Factors
- From:
Chinese Journal of Contemporary Pediatrics
2019;21(10):1055-1058
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the concept of "augmented renal clearance" (ARC) has been proposed in the field of critical illness and is defined as enhanced renal clearance of drugs. ARC is considered when the creatinine clearance rate exceeds 130 mL/(min·1.73 m). An increasing number of evidence has shown that ARC is commonly seen in critically ill adults and children. In critically ill children, low drug concentration due to ARC may lead to treatment failure. Unfortunately, ARC is often neglected due to the lack of reliable tools to assess renal function in critically ill children. Therefore, with reference to the articles on ARC in critically ill children, this article reviews the concept of ARC, the pathogenesis of ARC, the influencing factors for ARC, the identification tools for ARC, and the influence of ARC on pharmacokinetics/pharmacodynamics of antibacterial agents and clinical outcome, in order to provide a reference for clinical medication.
