A review on muscle-specific microRNAs as the biomarker for Duchenne muscular dystrophy.
- Author:
Qi MENG
1
;
Dan LAN
Author Information
1. Department of Pediatrics, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. land6785@163.com.
- Publication Type:Journal Article
- MeSH:
Biomarkers;
Creatine Kinase;
Humans;
MicroRNAs;
Muscle, Skeletal;
Muscular Dystrophy, Duchenne;
genetics
- From:
Chinese Journal of Contemporary Pediatrics
2019;21(11):1148-1152
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNA (miRNA) is a non-coding single-stranded RNA with a length of approximately 22 nucleotides and is mainly responsible for the regulation of gene expression at the post-transcriptional level. At present, miRNA have become potential biomarkers for various diseases such as tumor, leukemia, and nervous system disease. Muscle-specific microRNAs are enriched in the skeletal muscle of patients with Duchenne muscular dystrophy (DMD) and also play an important role in the pathogenesis of DMD. Creatine kinase has limited specificity in the diagnosis of DMD since its level is not significantly associated with disease severity, and therefore, it is of great clinical significance to explore whether muscle-specific microRNAs can be used as ideal biomarkers for DMD. This article reviews the research advances in this field.
