Infection is Associated with Occurrence of Proteinuria in Type 2 Diabetes Patients: A Systemic Review and Meta-Analysis.

Yan Shi; Jia-yu Duan; Dong-wei Liu; Ying-jin Qiao; Qiu-xia Han; Shao-kang Pan; Li Tang; Guang-yan Cai; Xiang-mei Chen; Zhang-suo Liu; Han-yu Zhu

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Infection is Associated with Occurrence of Proteinuria in Type 2 Diabetes Patients: A Systemic Review and Meta-Analysis.

Author: Yan SHI ^{1
,

2
,

3} ; Jia-Yu DUAN ^{3
,

4} ; Dong-Wei LIU ^{3
,

4} ; Ying-Jin QIAO ^{3
,

4} ; Qiu-Xia HAN ^{1
,

2
,

3} ; Shao-Kang PAN ^{3
,

4} ; Li TANG ⁵ ; Guang-Yan CAI ⁵ ; Xiang-Mei CHEN ⁵ ; Zhang-Suo LIU ^{3
,

4} ; Han-Yu ZHU ⁵
Author Information

1. Department of Nephrology, Chinese People's Liberation Army General Hospital, Chinese People's Liberation Army Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing 100853
2. Department of Nephrology, Zhengzhou University
3. The First Affiliated Hospital of Zhengzhou University, Research Institute of Nephrology, Key Laboratory of Accurate Diagnosis and Treatment of Chronic Kidney Diseases in Henan Province, Core Unit of National Kidney Disease Clinical Medical Research Center, Zhengzhou, Henan 450052, China.
4. Department of Nephrology, Zhengzhou University
5. Department of Nephrology, Chinese People's Liberation Army General Hospital, Chinese People's Liberation Army Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing 100853, China.
Publication Type:Journal Article
Keywords: Helicobacter pylori; Kidney; Meta-Analysis; Proteinuria; Type 2 Diabetes
MeSH: Confidence Intervals; Diabetes Mellitus, Type 2; metabolism; microbiology; Helicobacter Infections; metabolism; microbiology; Humans; Kidney; metabolism; Proteinuria; metabolism; microbiology
From: Chinese Medical Journal 2018;131(22):2734-2740
CountryChina
Language:English
Abstract: Background:Type 2 diabetes (T2DM) patients are susceptible to Helicobacter pylori (HP), and it has been reported that the occurrence of proteinuria is associated with HP infection in T2DM patients; however, this view remains controversial. This meta-analysis aimed to explore the association between HP infection and the occurrence of proteinuria in T2DM patients. In addition, we hope to provide some recommendations to readers in clinical or related fields.
Methods:Our meta-analysis was conducted with the methodology of the Cochrane Collaboration. Search strategies were formulated by relevant professionals. Case-control studies that compared the occurrence of proteinuria in T2DM patients with and without HP infection were involved in our meta-analysis. Relevant English or Chinese studies were searched on online databases before 2018, including PubMed, the Cochrane library, Medline, Google Scholar, the China National Infrastructure, and Wanfang database. The search strategies were "diabetic proteinuria, diabetic microalbuminuria, diabetic albuminuria, diabetic kidney disease, diabetic renal dysfunction, diabetic renal disease, diabetic nephropathy, diabetic complications, and diabetic mellitus, combined with HP." The quality of these involved articles was separately assessed by two investigators using the Newcastle-Ottawa Scale (NOS). Odds ratios (ORs) and associated 95% confidence intervals (CIs) were extracted and pooled using fixed-effects models.
Results:Seven studies involving 1029 participants were included. The quality of these seven articles was all above five stars as assessed by NOS, and there was no significant publication bias in our meta-analysis. We found that T2DM patients with HP infection had a 2.00 times higher risk of the occurrence of proteinuria than patients without HP infection (OR: 2.00, 95% CI: 1.48-2.69).
Conclusions:Our analysis showed that HP infection was associated with the occurrence of proteinuria in T2DM patients. HP radical surgery might be a therapeutic option for protecting kidney function in patients with T2DM.