Emerging transporter-targeted nanoparticulate drug delivery systems.
10.1016/j.apsb.2018.10.005
- Author:
Hongyan SU
1
;
Yan WANG
1
;
Shuo LIU
1
;
Yue WANG
1
;
Qian LIU
1
;
Guangxuan LIU
1
;
Qin CHEN
1
Author Information
1. Department of Pharmacy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang 110042, China.
- Publication Type:Journal Article
- Keywords:
Brain-targeting;
Nano-DDS;
Oral delivery;
Transporter;
Tumor-targeting
- From:
Acta Pharmaceutica Sinica B
2019;9(1):49-58
- CountryChina
- Language:English
-
Abstract:
Transporter-targeted nanoparticulate drug delivery systems (nano-DDS) have emerged as promising nanoplatforms for efficient drug delivery. Recently, great progress in transporter-targeted strategies has been made, especially with the rapid developments in nanotherapeutics. In this review, we outline the recent advances in transporter-targeted nano-DDS. First, the emerging transporter-targeted nano-DDS developed to facilitate oral drug delivery are reviewed. These include improvements in the oral absorption of protein and peptide drugs, facilitating the intravenous-to-oral switch in cancer chemotherapy. Secondly, the recent advances in transporter-assisted brain-targeting nano-DDS are discussed, focusing on the specific transporter-based targeting strategies. Recent developments in transporter-mediated tumor-targeting drug delivery are also discussed. Finally, the possible transport mechanisms involved in transporter-mediated endocytosis are highlighted, with special attention to the latest findings of the interactions between membrane transporters and nano-DDS.
