Preparation and characterization of multimodal hybrid organic and inorganic nanocrystals of camptothecin and gold.
10.1016/j.apsb.2018.03.005
- Author:
Christin P HOLLIS
1
;
Alan K DOZIER
2
;
Barbara L KNUTSON
3
;
Tonglei LI
4
Author Information
1. Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40506, USA.
2. Electron Microscopy Center, University of Kentucky, Lexington, KY 40506, USA.
3. Department of Chemical Engineering and Material Sciences, University of Kentucky, Lexington, KY 40506, USA.
4. Department Industrial & Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
- Publication Type:Journal Article
- Keywords:
Camptothecin;
Cancer therapy and diagnosis;
Computed tomography (CT) contrast agent;
Drug delivery;
Gold nanoparticles;
Hybrid inorganic-organic
- From:
Acta Pharmaceutica Sinica B
2019;9(1):128-134
- CountryChina
- Language:English
-
Abstract:
We demonstrate a novel inorganic-organic crystalline nanoconstruct, where gold atoms were imbedded in the crystal lattices as defects of camptothecin nanocrystals, suggesting its potential use as simultaneous agents for cancer therapy and bioimaging. The incorporation of gold, a potential computed tomography (CT) contrast agent, in the nanocrystals of camptothecin was detected by transmission electron microscope (TEM) and further quantified by energy dispersive X-ray spectrometry (EDS) and inductively coupled plasma-optical emission spectrometers (ICP-OES). Due to gold's high attenuation coefficient, only a relatively small amount needs to be present in order to create a good noise-to-contrast ratio in CT imaging. The imbedded gold atoms and clusters are expected to share the same biological fate as the camptothecin nanocrystals, reaching and accumulating in tumor site due to the enhanced permeation and retention (EPR) effect.
