Marine sponges of the genus as promising drug sources: chemical and biological aspects.
10.1016/j.apsb.2018.10.003
- Author:
Qihao WU
1
;
Bastien NAY
2
;
Min YANG
1
;
Yeke NI
1
;
Hong WANG
3
;
Ligong YAO
1
;
Xuwen LI
1
Author Information
1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China.
2. Laboratoire de Synthèse Organique (UMR 7652 CNRS), Ecole Polytechnique, Université Paris-Saclay, 91128 Palaiseau Cedex, France.
3. College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
- Publication Type:Journal Article
- Keywords:
Biological activity;
Isolation;
Marine drug leads;
Marine natural products;
Stelletta sponge;
Total synthesis
- From:
Acta Pharmaceutica Sinica B
2019;9(2):237-257
- CountryChina
- Language:English
-
Abstract:
Marine sponges of the genus are well known as rich sources of diverse and complex biologically relevant natural products, including alkaloids, terpenoids, peptides, lipids, and steroids. Some of these metabolites, with novel structures and promising biological activities, have attracted a lot of attention from chemists seeking to perform their total synthesis in parallel to intensive biological studies towards new drug leads. In this review, we summarized the distribution of the chemically investigated sponges, the isolation, synthesis and biological activities of their secondary metabolites, covering the literature from 1982 to early 2018.
