Multifunctional oral delivery systems for enhanced bioavailability of therapeutic peptides/proteins.
10.1016/j.apsb.2019.01.004
- Author:
Ying HAN
1
;
Zhonggao GAO
1
;
Liqing CHEN
1
;
Lin KANG
1
;
Wei HUANG
1
;
Mingji JIN
1
;
Qiming WANG
1
;
You Han BAE
2
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
2. Department of Pharmaceutics and Pharmaceutical Chemistry, the University of Utah, Salt Lake City, UT 84108, USA.
- Publication Type:Journal Article
- Keywords:
Bioavailability;
Epithelial barriers;
Gastrointestinal environment;
Macromolecules;
Multifunctional delivery systems;
Nanoparticles;
Oral;
Peptides and proteins
- From:
Acta Pharmaceutica Sinica B
2019;9(5):902-922
- CountryChina
- Language:English
-
Abstract:
In last few years, therapeutic peptides/proteins are rapidly growing in drug market considering their higher efficiency and lower toxicity than chemical drugs. However, the administration of therapeutic peptides/proteins is mainly limited in parenteral approach. Oral therapy which was hampered by harsh gastrointestinal environment and poorly penetrating epithelial barriers often results in low bioavailability (less than 1%-2%). Therefore, delivery systems that are rationally designed to overcome these challenges in gastrointestinal tract and ameliorate the oral bioavailability of therapeutic peptides/proteins are seriously promising. In this review, we summarized various multifunctional delivery systems, including lipid-based particles, polysaccharide-based particles, inorganic particles, and synthetic multifunctional particles that achieved effective oral delivery of therapeutic peptides/proteins.
