Deuteromethylactin B from a Freshwater-derived Streptomyces sp..
10.20307/nps.2015.21.4.261
- Author:
Anam F SHAIKH
1
;
Maryam ELFEKI
;
Samantha LANDOLFA
;
Urszula TANOUYE
;
Stefan J GREEN
;
Brian T MURPHY
Author Information
1. Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL 60612, USA. btmurphy@uic.edu
- Publication Type:Original Article
- Keywords:
Actinomycete;
Freshwater;
Streptomyces;
Octalactin
- MeSH:
Bacteria;
Fermentation;
Fresh Water;
Lakes;
Michigan;
Streptomyces*
- From:Natural Product Sciences
2015;21(4):261-267
- CountryRepublic of Korea
- Language:English
-
Abstract:
Compared to their terrestrial and marine counterparts, little is known about the capacity of freshwater-derived actinomycete bacteria to produce novel secondary metabolites. In the current study, we highlight the disparities that exist between cultivation-independent and -dependent analyses of actinomycete communities from four locations in Lake Michigan sediment. Furthermore, through phylogenetic analysis of strains isolated from these locations, we identified a Streptomyces sp., strain B025, as being distinct from other Streptomyces spp. isolated from sediment. Upon fermentation this strain produced a rare class of eight-membered lactone secondary metabolites, which have been for their antitumor properties. We used spectroscopic and chemical derivitization techniques to characterize octalactin B (1) in addition to its corresponding novel, unnatural degradation product (2).
