ReVersible Change of Vision in Patients Receiving Deferoxamine.
- Author:
Myung Jin PARK
1
;
Moon Sik CHO
;
Joon Soon KIM
Author Information
1. Department of Ophthalmology, Soonchunhyang University College of Medicine, Chunan, Korea. cms3445@hanmir.com
- Publication Type:Case Report
- Keywords:
Deferoxamine;
Paraquat;
Visual neurotoxicity
- MeSH:
Adult;
Constriction;
Deferoxamine*;
Evoked Potentials, Visual;
Female;
Humans;
Infusions, Intravenous;
Middle Aged;
Paraquat;
Poisoning;
Visual Acuity;
Visual Fields
- From:Journal of the Korean Ophthalmological Society
2004;45(8):1397-1401
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To report 2 cases of acute visual neurotoxicity in patients with paraquat poisoning receiving deferoxamine. METHODS: A 48-year-old woman and a 37-year-old man received intravenous infusion of deferoxamine at 3g/day for 7 days for treatment of paraquat poisoning. They presented with severely impaired visual acuity, generalized constriction of visual field, and decreased amplitude of visual evoked potential. They improved clinically upon drug-withdrawal. CONCLUSIONS: Deferoxamine is an effective agent for treatment of paraquat poisoning, but can cause visual neurotoxicity. We recommend careful regulation of the deferoxamine dosage and serial visual monitoring in patients receiving the drug.
