A systematic review of the association of obesity with the outcomes of inflammatory rheumatic diseases.

Yi Xuan Lee; Yu Heng Kwan; Ka Keat Lim; Chuen Seng Tan; Nai Lee Lui; Jie Kie Phang; Eng Hui Chew; Truls Ostbye; Julian Thumboo; Warren Fong

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A systematic review of the association of obesity with the outcomes of inflammatory rheumatic diseases.

Author: Yi Xuan LEE ¹ ; Yu Heng KWAN ² ; Ka Keat LIM ² ; Chuen Seng TAN ³ ; Nai Lee LUI ⁴ ; Jie Kie PHANG ⁴ ; Eng Hui CHEW ¹ ; Truls OSTBYE ² ; Julian THUMBOO ⁴ ; Warren FONG ⁴
Author Information

1. Department of Pharmacy, National University of Singapore, Singapore.
2. Programme in Health Services and Systems Research, Duke-NUS Medical School, Singapore.
3. Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
4. Department of Rheumatology and Immunology, Singapore General Hospital, Singapore.
Publication Type:Journal Article
Keywords: association; obesity; outcomes; rheumatology
From:Singapore medical journal 2019;60(6):270-280
CountrySingapore
Language:English
Abstract: This was a systematic review of the literature on the association between obesity and the outcome of inflammatory rheumatic diseases. We conducted a literature search using PubMed®, Embase and PsycINFO®. Articles were classified into three categories based on the effects of obesity on the outcomes of inflammatory rheumatic diseases. The subject population, country, type of studies, number of patients, measurement of obesity and outcomes assessed were presented. Quality was appraised using Kmet et al's criteria. 4,331 articles were screened and 60 were relevant to the objective. Obesity had a negative, positive and neutral association with outcomes of inflammatory rheumatic diseases in 38 (63.3%) studies with 57,612 subjects, 11 (18.3%) studies with 3,866 subjects, and 11 (18.3%) studies with 3,834 subjects, respectively. In most studies, the disease population had been diagnosed with rheumatoid arthritis (RA). Tumour necrosis factor-α inhibitors were mostly associated with negative outcomes. More studies examining subjects outside Europe and North America and diseases other than RA are warranted.