Effects of pungent essential oil from three Chinese herbs on percutaneous absorption of alkaloids from Sophorae Flavescentis Radix.
10.19540/j.cnki.cjcmm.20181108.001
- Author:
Ling WANG
1
;
Ting ZHANG
1
;
Da-Wei QIAN
1
;
Zhen-Hua ZHU
1
;
Chun-Xue WANG
1
;
Ze-Bin WENG
1
;
Huang-Qin ZHANG
1
;
Sheng GUO
1
;
Shu-Lan SU
2
;
Jin-Ao DUAN
2
Author Information
1. Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization/Jiangsu Key Laboratory for High Technology Research of Traditional Chinese Medicine Formulae,Nanjing University of Chinese Medicine Nanjing 210023,China.
2. Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization/Jiangsu Key Laboratory for High Technology Research of Traditional Chinese Medicine Formulae,Nanjing University of Chinese Medicine Nanjing 210023,China National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine,Nanjing University of Chinese Medicine Nanjing 210023,China.
- Publication Type:Journal Article
- Keywords:
Sophorae Flavescentis Radix;
alkaloids;
essential oil;
percutaneous absorption;
pungent herbs
- MeSH:
Alkaloids;
metabolism;
Animals;
Chromatography, High Pressure Liquid;
Drugs, Chinese Herbal;
metabolism;
Oils, Volatile;
pharmacology;
Plant Roots;
chemistry;
Rats;
Rats, Sprague-Dawley;
Skin Absorption;
Sophora;
chemistry
- From:
China Journal of Chinese Materia Medica
2019;44(2):308-313
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the effects of essential oil from three kinds of pungent herbs,namely Menthae Haplocalycis Herba,Atractylodis Rhizoma and Cnidii Fructus,on the transdermal absorption in vitro of alkaloids from Sophorae Flavescentis Radix. The modified vertical Franz diffusion cell was used to conduct a transdermal experiment in vitro with the isolated abdominal skin of the SD rats as the transdermal absorption barrier. The effects of such three kinds of pungent essential oil on percutaneous absorption of alkaloids from Sophorae Flavescentis Radix were investigated by determining the content of 6 alkaloids( oxymatrine,oxysophocarpine,N-methylcytisine,sophoridine,matrine,and sophocarpidine) in the transdermal acceptor with ultra-performance liquid chromatography-triple quadruple mass spectrometry( UPLC-TQ-MS) technique simultaneously. With enhancement ratio( ER) as the index,their effects on promoting penetration was as follows: 1% Atractylodis Rhizoma oil > 1% Cnidii Fructus oil > 3% Azone ≈ 3% Atractylodis Rhizoma oil > 5%Atractylodis Rhizoma oil > 3% Cnidii Fructus oil ≈ 5% Cnidii Fructus oil > 3% Menthae Haplocalycis Herba oil > 5% Menthae Haplocalycis Herba oil > 1% Menthae Haplocalycis Herba oil > Blank. The results showed that these three kinds of pungent essential oil could be used as enhancers for alkaloids of Sophorae Flavescentis Radix,providing scientific guidance for improving percutaneous absorption of alkaloids from Sophorae Flavescentis Radix.
