Studies on chemical constituents of Isodon henryi.
10.19540/j.cnki.cjcmm.20181101.009
- Author:
Ling-Xia ZHANG
1
;
Ya-Lin LIU
1
;
Hong WU
2
;
Sui-Qing CHEN
1
;
Li-Ping DAI
1
Author Information
1. College of Pharmacy,Henan University of Chinese Medicine Zhengzhou 450046,China.
2. Laboratory of Cell Imaging,Henan University of Chinese Medicine Zhengzhou 450002,China.
- Publication Type:Journal Article
- Keywords:
Isodon henryi;
cytotoxic;
diterpenes;
structural identification
- MeSH:
Isodon;
chemistry;
Magnetic Resonance Spectroscopy;
Molecular Structure;
Phytochemicals;
analysis;
Plant Components, Aerial;
chemistry;
Plant Extracts;
chemistry
- From:
China Journal of Chinese Materia Medica
2019;44(2):319-323
- CountryChina
- Language:Chinese
-
Abstract:
The chemical constituents of the water extraction of the aerial parts of Isodon henryi were investigated by various chromatographic methods including D-101 macroporous adsorptive resins,silica gel,sephadex LH-20,and semi-preparative HPLC. As a result,ten compounds were separated and purified. By analyses of the UV,IR,MS,NMR spectra,their structures were determined as rabdosinate( 1),lasiokaurin( 2),epinodosinol( 3),rabdosichuanin C( 4),epinodosin( 5),hebeirubescensin k( 6),rubescensin C( 7),enmenol( 8),oridonin( 9),and enmenol-1-β-glucoside( 10). Compounds 1-8 and 10 were isolated from I. henryi for the first time. Compounds 2 and 9 showed inhibitory effects against four tumor cells,with IC50 values of 2. 25-9. 32 μmol·L-1.
