Compound traditional Chinese medicine in treatment of diabetes.
10.19540/j.cnki.cjcmm.20181212.001
- Author:
Qing-Hua WU
1
;
Bing-Tao LI
2
;
Jun TU
2
Author Information
1. Research Center for Differentiation and Development of Traditional Chinese Medicine Basic Theory,Jiangxi University of Traditional Chinese Medicine Nanchang 330004,China Jiangxi Province Key Laboratory of Traditional Chinese Medicine Pharmacology Nanchang 330004,China.
2. Research Center for Differentiation and Development of Traditional Chinese Medicine Basic Theory,Jiangxi University of Traditional Chinese Medicine Nanchang 330004,China.
- Publication Type:Journal Article
- Keywords:
clinical trial;
diabetes;
herbal formula;
mechanism of action
- MeSH:
Diabetes Mellitus;
drug therapy;
Drugs, Chinese Herbal;
Humans;
Hypoglycemic Agents;
Medicine, Chinese Traditional
- From:
China Journal of Chinese Materia Medica
2019;44(6):1104-1109
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes is a chronic disorder of glucose metabolism characterized by elevated blood glucose levels. With the improvement in living standards and the changes in lifestyle,T2 DM incidence has a dramatic increase in the past decades,bringing a series of public health problems. In the research and development field of diabetic drugs,T1 DM drugs are mainly long-acting sustained-release insulin preparations,whereas T2 DM drugs mainly are based on single target. T2 DM drugs usually have a good anti-hyperglycemic effect,but with side effects for long-term administration. Therefore,the research and development of hypoglycemic drugs focus on formula drugs with multi-component,multi-target and multi-pathway effects. In the similar principle of action,traditional Chinese medicine formula has achieved a good efficacy in the treatment of diabetes,with mild anti-hyperglycemic effects and multiple-component synergistic effects in intervening the pathogenesis of diabetes,including additive effect,synergy effect and toxicity scattering effect. This article mainly reviews clinical trials and mechanisms of action of traditional Chinese medicine formula for the treatment of diabetes,so as to provide a reference to the rational and effective clinical application of traditional Chinese medicine formula in treating diabetes.
