Protective effect of Yindan Pinggan Capsules on liver inflammatory injury and oxidative stress induced by acute alcoholic intake.
10.19540/j.cnki.cjcmm.20190107.002
- Author:
Juan YU
1
Author Information
1. Zhangzhou Pien Zai Huang Parmaceutical Co.,Ltd. Zhangzhou 363000,China.
- Publication Type:Journal Article
- Keywords:
Yindan Pinggan Capsules;
acute alcoholic hepatitis;
inflammatory factors;
oxidative stress
- MeSH:
Animals;
Capsules;
Liver;
Male;
Oxidative Stress;
Rats;
Rats, Sprague-Dawley;
Tumor Necrosis Factor-alpha
- From:
China Journal of Chinese Materia Medica
2019;44(6):1233-1237
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the protective effect of Yindan Pinggan Capsules(YDPG)on acute alcoholic liver inflammatory injury and oxidative stress,sixty male Sprague-Dawley rats were divided into 6 groups randomly:normal group,model group,YDPG-L group,YD-PG-M group,YDPG-H group and Haiwang Jinzun(HWJZ)group.Except for the normal rats,while the remaining rats were administered orally with alcohol(50%,5 g·kg~(-1)).One hour after drinking,the rats in normal or model group were administered orally with PS,while the remaining rats were separately given YDPG(0.15,0.3,0.6 g·kg~(-1))or HWJZ(0.3 g·kg~(-1))for 10 days.After the last intragastric administration and fasting for 8 h,the HE staining was used to observe the pathological changes.The serum was used to determine the content of ALT,AST,ALP,TB,TP,LDH.The expressions of IL-1β,TNF-α,IL-10 and IL-4 in serum were detected by enzyme-linked immuno sorbent assay(ELISA).The content of SOD,MDA,GSH,GSP-Px in liver were determined.The results showed that both YDPGand HWJZ alleviated the liver injury induced by alcohol,decreased the activities of ALT,AST,ALP and LDH,down-regulated the expressions of TNF-αand IL-1β,up-regulated the expressions of IL-4 and IL-10;increased the activities of SOD,GSH,GSH-Px,but decreased the content of MDA.Therefore,the above results indicated that YDPG could protect the liver from alcoholic injury.
