Molecular mechanisms of insulin resistance and interventional effects of Chinese herbal medicine.
10.19540/j.cnki.cjcmm.20181105.003
- Author:
Hong-Yun YEE
1
;
Jing-Jing YANG
2
;
Yi-Gang WAN
3
;
Fee-Lan CHONG
4
;
Wei WU
3
;
Yan LONG
3
;
Wen-Bei HAN
1
;
Ying-Lu LIU
1
;
Yue TU
5
;
Jian YAO
6
Author Information
1. Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing 210008, China.
2. Department of Nephrology, Taicang Traditional Chinese Medicine Hospital Taicang 215400, China.
3. Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School Nanjing 210008, China.
4. Management and Science University Kuala Lumpur 40100, Malaysia.
5. Department of Traditional Chinese Medicine Health Preservation, Second Clinic Medical School, Nanjing University of Chinese Medicine Nanjing 210023, China.
6. Division of Molecular Signaling,Department of Advanced Biomedical Research, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi Yamanashi 409-3898, Japan.
- Publication Type:Journal Article
- Keywords:
Chinese herbal medicine;
insulin resistance;
molecular mechanism;
signaling pathway
- MeSH:
Drugs, Chinese Herbal;
therapeutic use;
Humans;
Insulin;
Insulin Resistance;
Signal Transduction
- From:
China Journal of Chinese Materia Medica
2019;44(7):1289-1294
- CountryChina
- Language:Chinese
-
Abstract:
It is considered that insulin resistance(IR)and its signaling pathway disorder are one of pathogenesis that causes insulin target-organs/issues lesions and their slow progression. The clinical diagnosis index of IR is the homeostatic model of insulin resistance(HOMA-IR)based on fasting blood-glucose and fasting serum insulin. Furthermore, the emerging IR biomarkers including adiponectin may be the references for clinical diagnosis. The influence factors of IR are obesity, chronic microinflammation and a lack of exercise. The major signaling pathways of IR include insulin receptor substrate 1(IRS1)/phosphatidylinositiol-3-kinase(PI3 K)/serine-threonine kinase(Akt)pathway, mitogen-activated protein kinase(MAPK)pathway and Smad3 pathway. In clinics, insulin sensibility and IR could be increased and improved via promoting insulin secretion and enhancing insulin signaling activation. At present, insulin sensitizers treating IR not only have the classic thiazolidinediones and its ramifications but also have the newly discovered metformin and vitamin D. In addition, it is reported that some extracts from single Chinese herbal medicine(CHM)and Chinese herbal compound prescription such as total flavone from the flowers of Abelmoschl manihot, berberine, astragalus polysaccharides and Huang-qi decoction also have the beneficial effects in ameliorating IR. In the field of chronic kidney disease, targeting a common insulin target-organs/issues lesion, the early renal damage in diabetic mellitus, the intervention studies regarding to regulating podocyte IR signaling pathways by CHM will be one of the significant directions in the future.
