Lignans from seed of Hydnocarpus anthelminthica.
10.19540/j.cnki.cjcmm.20190118.008
- Author:
Rui-Lan LIANG
1
;
Guo-Ru SHI
2
;
Shi-Shan YU
2
Author Information
1. Guangxi University of Chinese Medicine Nanning 530200, China.
2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050, China.
- Publication Type:Journal Article
- Keywords:
Flacourtiaceae;
H.anthelminthica;
Hydnocarpus Gaertn;
chemical constituents;
lignan
- MeSH:
Lignans;
analysis;
Magnoliopsida;
chemistry;
Molecular Structure;
Phytochemicals;
analysis;
Plant Extracts;
analysis;
Seeds;
chemistry
- From:
China Journal of Chinese Materia Medica
2019;44(7):1397-1402
- CountryChina
- Language:Chinese
-
Abstract:
This project is to investigate lignans from the seed of Hydnocarpus anthelminthica. Thirteen lignans were isolated from the 95% ethanol extract of the seed of H. anthelminthica, by polyamide resin, Sephadex LH-20, ODS column chromatography and preparative HPLC. Their structures were elucidated as(+)-syringaresinol(1), lirioresinol A(2),(+)-medioresinol(3),(7R,8R,8'R)-4'-guaiacylglyceryl-evofolin B(4), leptolepisol C(5),(-)-(7R,7'R,7″R,8S,8'S,8″S)-4',4″-dihydroxy-3,3',3″,5,5',5″-hexamethoxy-7,9':7',9-diepoxy-4,8″-oxy-8,8'-sesquineolignan-7″,9″-diol(6),(-)-(7R,7'R,7″R,8S,8'S,8″S)-4',4″-dihydroxy-3,3',3″,5,5'-pentamethoxy-7,9':7',9-diepoxy-4,8″-oxy-8,8'ses-quineolignan-7″,9″-diol(7), ceplignan(8), hydnocarpusol(9), isohydnocarpin(10),(-)-hydnocarpin(11), hydnocarpin(12), and hydnocarpin-D(13) by spectroscopic data analysis. Compounds 1-8 were obtained from the genus Hydnocarpus for the first time.
