Effect of single-herb traditional Chinese medicine for eliminating dampness on metabolism of uric acid.
10.19540/j.cnki.cjcmm.20181213.004
- Author:
Meng-Zhen CHU
1
;
Bing ZHANG
1
;
Zhi-Jian LIN
1
;
Xiao-Meng ZHANG
1
;
Yu WANG
1
Author Information
1. School of Chinese Pharmacy, Beijing University of Chinese Medicine Beijing 100029, China.
- Publication Type:Journal Article
- Keywords:
damp evil;
traditional Chinese medicine for eliminating dampness;
uric acid
- MeSH:
Drugs, Chinese Herbal;
therapeutic use;
Humans;
Hyperuricemia;
drug therapy;
Medicine, Chinese Traditional;
Uric Acid;
metabolism
- From:
China Journal of Chinese Materia Medica
2019;44(7):1485-1490
- CountryChina
- Language:Chinese
-
Abstract:
Through literature review, it was found that there were many literature reports on the effect of single-herb traditional Chinese medicine for lowering uric acid in comparison with other single-herb traditional Chinese medicines. Then what is the relationship between single-herb traditional Chinese medicines for eliminating dampness and uric acid? How do they play a role in lowering uric acid? In this study, traditional Chinese medicines for eliminating dampness in the 2015 Chinese Pharmacopoeia and the innovative textbook of Clinical Chinese Pharmacy for Chinese medicine colleges and universities in the new century were selected as the research objects, and articles about the effect of single-herb traditional Chinese medicines for eliminating dampness in the treatment of hyperuricemia were searched through CNKI, WanFang and VIP. Afterwards, Excel(2016) was used to establish a database, and Excel screening tool was used to extract the classification statistics of its uric acid lowering effect, pharmacodynamic sites, uric acid lowering pathway and mechanism, so as to clarify the relationship between single-herb traditional Chinese medicines for eliminating dampness and uric acid as well as their mechanism on lowering uric acid. The results showed that there were 16 kinds of traditional Chinese medicines with uric acid lowering effect, accounting for 23.88% of the 67 kinds of traditional Chinese medicines for eliminating dampness. Other medicines with the uric acid lowering effect included traditional Chinese medicine extracts and chemical components. The main ways of reducing uric acid included: inhibiting uric acid synthesis and promoting uric acid excretion; mechanism of action was mainly regulating the two key enzymes generated by uric acid and the ion transporters excreted by uric acid. Therefore, it can be seen that this kind of traditional Chinese medicines have a clear effect in reducing uric acid, providing new ideas for drug screening, prescription compatibility and target determination for the treatment of hyperuricemia as well as a theoretical basis for the clinical treatment and research of hyperuricemia.
