Current status and future prospect of pharmacotherapy for pancreatic cancer.
10.19540/j.cnki.cjcmm.20190104.002
- Author:
Yun FANG
1
;
Meng-Ru LAI
1
;
Yu-Qing GE
2
;
Guang-Ji ZHANG
1
;
Ru-Bin CHENG
1
Author Information
1. College of Pharmaceutical Science,Zhejiang Chinese Medical University Hangzhou 310053,China.
2. the First Affiliated Hospital,Zhejiang Chinese Medical University Hangzhou 310006,China.
- Publication Type:Journal Article
- Keywords:
pancreatic cancer;
pharmacotherapy;
review;
traditional Chinese medicine treatment
- MeSH:
Forecasting;
Humans;
Medicine, Chinese Traditional;
Pancreatic Neoplasms;
drug therapy
- From:
China Journal of Chinese Materia Medica
2019;44(8):1509-1516
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic cancer is the most common digestive tract tumor with an increasing incidence in recent years. The poor prognosis of pancreatic cancer is mainly because of the inability of detecting tumor at an early stage,its high potential for early dissemination,and its relatively poor sensitivity to chemotherapy. Most patients have lost the opportunity for surgery when they are diagnosed,which resulted in an urgent need for the development of more effective and safe therapies for pancreatic cancer. However,the current clinical cancer chemotherapy based on gemcitabine leads to poor prognosis in pancreatic patients. With the continuous research on the biological and cellular signaling pathways of pancreatic cancer,there have emerged a great many of novel agents,including new chemotherapeutic,targetable and immune-modulatory drugs,and some drugs have achieved encouraging results. Furthermore,as an alternative and supplementary method,traditional Chinese medicine has shown good application prospects in the field of pancreatic cancer treatment. This article reviews the current status of drug therapy for pancreatic cancer,summarizes the strength and weakness of existing therapeutic drugs in the application process,gives prospects of possible breakthroughs for the pharmacotherapy in the future,and provides certain new ideas and lessons for subsequent drug development.
